The Rock's ungainly performance is somewhat alleviated by Karl Urban as a crew member and Rosamund Pike as his twin sister, a doctor on the project.

What might have made for exciting action scenes tend to become mechanical exercises in first-person-shooter monster-blasting.

I kept expecting the "Game Over" message to flash up, but it never did.

Characters keep disappearing and reappearing without explanation and comic moments and moral messages - don't do drugs, genetic tampering is wrong - jar against the action backdrop.